金刚烷胺：一种治疗微意识状态的潜在疗法。

Amantadine: a potential treatment for the minimally conscious state.

作者信息

Zafonte R D, Watanabe T, Mann N R

机构信息

Rehabilitation Institute of Michigan, Wayne State University, Detroit, USA.

出版信息

Brain Inj. 1998 Jul;12(7):617-21. doi: 10.1080/026990598122386.

DOI:10.1080/026990598122386

PMID:9653525

Abstract

Pharmacologic strategies have been advocated to enhance the neurorehabilitation of persons with severe traumatic brain injury. Dopaminergic pathways have been felt to play a significant role in arousal. Employing single case design methodology we present the case of a survivor of severe traumatic brain injury who appeared to have a dose dependent response to the pro-dopaminergic medication amantadine. Further research is necessary to clarify the role of pharmacotherapy in the improvement of functional outcome.

摘要

药理学策略已被提倡用于加强重度创伤性脑损伤患者的神经康复。多巴胺能通路被认为在觉醒中起重要作用。采用单病例设计方法，我们报告了一名重度创伤性脑损伤幸存者的病例，该患者似乎对促多巴胺能药物金刚烷胺有剂量依赖性反应。有必要进行进一步研究以阐明药物治疗在改善功能结局中的作用。