实验性创伤性脑损伤治疗方案的生物学和塑性效应及其与临床康复的相关性。
Biologic and plastic effects of experimental traumatic brain injury treatment paradigms and their relevance to clinical rehabilitation.
机构信息
Department of Physical Medicine and Rehabilitation, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15213, USA.
出版信息
PM R. 2011 Jun;3(6 Suppl 1):S18-27. doi: 10.1016/j.pmrj.2011.03.017.
Abstract
Neuroplastic changes, whether induced by traumatic brain injury (TBI) or therapeutic interventions, alter neurobehavioral outcome. Here we present several treatment strategies that have been evaluated by using experimental TBI models and discuss potential mechanisms of action (ie, plasticity) and how such changes affect function.
摘要
神经重塑变化，无论是由创伤性脑损伤（TBI）还是治疗干预引起的，都会改变神经行为结果。在这里，我们提出了几种已经通过实验性 TBI 模型进行评估的治疗策略，并讨论了潜在的作用机制（即可塑性）以及这些变化如何影响功能。
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