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实验性创伤性脑损伤治疗方案的生物学和塑性效应及其与临床康复的相关性。

Biologic and plastic effects of experimental traumatic brain injury treatment paradigms and their relevance to clinical rehabilitation.

机构信息

Department of Physical Medicine and Rehabilitation, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15213, USA.

出版信息

PM R. 2011 Jun;3(6 Suppl 1):S18-27. doi: 10.1016/j.pmrj.2011.03.017.

DOI:10.1016/j.pmrj.2011.03.017
PMID:21703575
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3146549/
Abstract

Neuroplastic changes, whether induced by traumatic brain injury (TBI) or therapeutic interventions, alter neurobehavioral outcome. Here we present several treatment strategies that have been evaluated by using experimental TBI models and discuss potential mechanisms of action (ie, plasticity) and how such changes affect function.

摘要

神经重塑变化，无论是由创伤性脑损伤（TBI）还是治疗干预引起的，都会改变神经行为结果。在这里，我们提出了几种已经通过实验性 TBI 模型进行评估的治疗策略，并讨论了潜在的作用机制（即可塑性）以及这些变化如何影响功能。

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本文引用的文献

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Acute serum hormone levels: characterization and prognosis after severe traumatic brain injury.急性血清激素水平：严重创伤性脑损伤后的特征和预后。
J Neurotrauma. 2011 Jun;28(6):871-88. doi: 10.1089/neu.2010.1586. Epub 2011 Jun 1.
2
Temporal effects of environmental enrichment-mediated functional improvement after experimental traumatic brain injury in rats.环境丰富化介导的实验性创伤性脑损伤后大鼠功能改善的时间效应。
Neurorehabil Neural Repair. 2011 Jul-Aug;25(6):558-64. doi: 10.1177/1545968310397206. Epub 2011 Mar 24.
3
Abbreviated environmental enrichment enhances neurobehavioral recovery comparably to continuous exposure after traumatic brain injury.缩短的环境丰容对创伤性脑损伤后神经行为恢复的促进作用与持续暴露相当。
Neurorehabil Neural Repair. 2011 May;25(4):343-50. doi: 10.1177/1545968310390520. Epub 2010 Dec 26.
4
Evaluation of a combined therapeutic regimen of 8-OH-DPAT and environmental enrichment after experimental traumatic brain injury.实验性创伤性脑损伤后 8-OH-DPAT 与环境富集联合治疗方案的评价。
J Neurotrauma. 2010 Nov;27(11):2021-32. doi: 10.1089/neu.2010.1535. Epub 2010 Oct 28.
5
Dilantin therapy in an experimental model of traumatic brain injury: effects of limited versus daily treatment on neurological and behavioral recovery.苯妥英钠治疗创伤性脑损伤的实验模型：有限治疗与每日治疗对神经功能和行为恢复的影响。
J Neurotrauma. 2011 Jan;28(1):43-55. doi: 10.1089/neu.2010.1521. Epub 2010 Dec 18.
6
Reorganization of motor cortex after controlled cortical impact in rats and implications for functional recovery.大鼠皮层撞击伤后运动皮层的重组及其对功能恢复的影响。
J Neurotrauma. 2010 Dec;27(12):2221-32. doi: 10.1089/neu.2010.1456. Epub 2010 Nov 22.
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Stress, sex, and neural adaptation to a changing environment: mechanisms of neuronal remodeling.压力、性别与神经适应不断变化的环境：神经元重构的机制。
Ann N Y Acad Sci. 2010 Sep;1204 Suppl(Suppl):E38-59. doi: 10.1111/j.1749-6632.2010.05568.x.
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Empirical comparison of typical and atypical environmental enrichment paradigms on functional and histological outcome after experimental traumatic brain injury.典型和非典型环境丰容范式对实验性创伤性脑损伤后功能和组织学结果的实证比较。
J Neurotrauma. 2010 Jun;27(6):1047-57. doi: 10.1089/neu.2010.1313.
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Involvement of pro- and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injury.促炎和抗炎细胞因子及趋化因子在创伤性脑损伤病理生理学中的作用。
Neurotherapeutics. 2010 Jan;7(1):22-30. doi: 10.1016/j.nurt.2009.10.016.
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Estrogen therapy and cognition: a review of the cholinergic hypothesis.雌激素治疗与认知：胆碱能假说述评。
Endocr Rev. 2010 Apr;31(2):224-53. doi: 10.1210/er.2009-0036. Epub 2009 Dec 17.