基于小分子的基因表达调控策略。

Small-molecule-based strategies for controlling gene expression.

作者信息

Denison C, Kodadek T

机构信息

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-8573, USA.

出版信息

Chem Biol. 1998 Jun;5(6):R129-45. doi: 10.1016/s1074-5521(98)90167-3.

DOI:10.1016/s1074-5521(98)90167-3

PMID:9653545

Abstract

A central goal in chemical biology is to gain control over biological pathways using small molecules, and the mRNA-synthesizing machinery is a particular important target. New advances in our understanding of transcriptional regulation suggests strategies to manipulate these pathways using small molecules.

摘要

化学生物学的一个核心目标是利用小分子来控制生物途径，而mRNA合成机制是一个特别重要的靶点。我们对转录调控理解的新进展提示了利用小分子操纵这些途径的策略。