Torre M L, Giunchedi P, Maggi L, Stefli R, Machiste E O, Conte U
Dipartimento di Chimica Farmaceutica, Università di Pavia, Italy.
Pharm Dev Technol. 1998 May;3(2):193-8. doi: 10.3109/10837459809028495.
The purpose of this work was the preparation and characterization of calcium alginate beads containing ampicillin. Aqueous solutions of drug and sodium alginate (three viscosity grades) were added drop by drop to aqueous solutions of calcium chloride; the droplets instantaneously formed gel beads, which were then dried. Morphological studies and drug contents, in vitro release, and erosion tests were carried out for the characterization of the prepared beads. The dried particles were characterized by irregular shape and a smooth or rough surface, depending on the viscosity grade of the alginate used. The control of the drug for different time intervals depended on the molecular weight of the polymer used; however, the pH-change test showed that this capacity was much lower in the case of acid-treated particles. The results obtained show that the ampicillin beads prepared are suitable for intramammary therapy.
这项工作的目的是制备并表征含有氨苄青霉素的海藻酸钙珠。将药物和海藻酸钠（三种粘度等级）的水溶液逐滴加入氯化钙水溶液中；液滴瞬间形成凝胶珠，然后进行干燥。对制备的珠子进行形态学研究、药物含量、体外释放和溶蚀试验以进行表征。干燥后的颗粒形状不规则，表面光滑或粗糙，这取决于所用海藻酸盐的粘度等级。不同时间间隔内药物的控制取决于所用聚合物的分子量；然而，pH变化试验表明，在酸处理颗粒的情况下，这种能力要低得多。所得结果表明，制备的氨苄青霉素珠适用于乳房内治疗。
