Rijli F M, Gavalas A, Chambon P
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, Strasbourg.
Int J Dev Biol. 1998;42(3):393-401.
Hox genes are segmentally expressed in the developing vertebrate hindbrain, neural crest cells and pharyngeal arches suggesting an important role in patterning these structures. Here we discuss the cellular and molecular mechanisms controlling segmentation and specification in the branchial region of the head. In addition, based on the recent phenotypical and molecular analysis of loss-of-function mutants in the mouse, we speculate that Hox genes may act like Drosophila selector genes in this system.
Hox基因在发育中的脊椎动物后脑、神经嵴细胞和咽弓中呈节段性表达，这表明其在这些结构的模式形成中发挥着重要作用。在此，我们讨论控制头部鳃区节段化和特化的细胞与分子机制。此外，基于对小鼠功能丧失突变体的最新表型和分子分析，我们推测Hox基因在该系统中可能类似于果蝇的选择基因。
