Osteen R T, Chaffey J T, Moore F D, Wilson R E
Surg Gynecol Obstet. 1978 Jul;147(1):75-9.
In a series of patients who were not candidates for mastectomy because of locally advanced disease or distant metastases, or both, excellent local control was obtained by radiation therapy and systemic therapy in the form of oophorectomy-adrenalectomy and chemotherapy. Local control was obtained in 12 of 15 patients with metastatic disease by systemic therapy without radiation. The median disease-free survival time for patients with advanced Stage III carcinoma of the breast was significantly prolonged from 9.5 to 15 months by oophorectomy-adrenalectomy with chemotherapy, although there was no definable difference in the over-all survival period for the two groups.
在一系列因局部晚期疾病或远处转移或两者兼有而不适合乳房切除术的患者中，通过放射治疗以及卵巢切除术-肾上腺切除术和化疗形式的全身治疗，获得了良好的局部控制。在15例转移性疾病患者中，有12例通过不进行放射治疗的全身治疗实现了局部控制。对于晚期III期乳腺癌患者，通过卵巢切除术-肾上腺切除术联合化疗，无病生存时间中位数从9.5个月显著延长至15个月，尽管两组的总生存期没有明显差异。
