Moore D T, McCleary R A
J Comp Physiol Psychol. 1976 Jan;90(1):109-18. doi: 10.1037/h0077263.
The purpose of this study was to compare the effects of fornix lesions with the deficits known to follow septum lesions in cats learning visual object discriminations. In Experiment 1 when eight cats with aspiration lesions of the fornix performed successive discrimination problems, acquisition was greatly facilitated, but first- and second-reversal scores were normal by comparison with eight normal cats and two operated corpus callosum-control cats without fornix damage. Four corpus callosum-damaged cats with secondary degeneration in the medial fornix also learned the initial problem faster than normals. In Experiment 2 in a simultaneous paradigm, eight cats with fornix lesions scored like five normal controls, although they perseverated in early stages of reversal problems. The authors hypothesize that medial fornix damage, in contrast with septum lesions, enhances both initiation and maintenance of response inhibition.
本研究的目的是比较穹窿损伤与猫在学习视觉物体辨别时已知的隔区损伤所导致的缺陷的影响。在实验1中，八只患有穹窿抽吸损伤的猫进行连续辨别任务时，习得过程得到极大促进，但与八只正常猫和两只未受穹窿损伤的胼胝体手术对照猫相比，首次和第二次反转分数正常。四只因内侧穹窿继发性变性而胼胝体受损的猫也比正常猫更快地学会了初始任务。在实验2的同时范式中，八只患有穹窿损伤的猫的得分与五只正常对照猫相似，尽管它们在反转问题的早期阶段存在固执行为。作者推测，与隔区损伤相比，内侧穹窿损伤增强了反应抑制的启动和维持。
