Pager J, Royet J P
J Comp Physiol Psychol. 1976 Jan;90(1):67-77. doi: 10.1037/h0077254.
Rats maintained on an unadulterated synthetic food, available from 8 a.m. to 10 a.m. everyday, were submitted to an aversive conditioning schedule on which a first ingestion of eucalyptol-flavored food (EF) was followed by an apomorphine injection (20 mg/kg, ip). In the first experiment the daily food intake was measured from Day 1 to 17, during the first and second hours of the meal. The EF was offered on Days 8, 9, and 17 during the first or the second hour of the meal (Series B or A). On Day 8, the meal was followed in a group of rats by the apomorphine injection. As compared with the intake of Day 8, the mean EF intake of Day 9 was significantly decreased in Series A and B, and of Day 17 in Series A only. No significant EF-intake modification could be observed in a saline-injected group or in an untreated control group. In the second experiment, rats bearing bulbar electrodes for the chronic recording of multiunit mitral cell responses received a 2-hr EF meal before the apomorphine injection. They were stimulated by puffs of odors of pure eucalyptol, unadulterated food, and EF and recorded in hungry and satiated states. Before the aversive conditioning, a significantly greater occurrence of positive responses to the odors of unadulterated food and EF was observed in hungry rats compared with satiated rats. The eucalyptol odor yielded equivalent patterns of responses in hungry and satiated rats before and after conditioning. Conditioning did not alter the modulated responses to unadulterated food odor (a greater occurrence of positive responses was still observed in hungry rats) but modified the responses to the odor of EF (the same high rate of positive responses was then observed in satiated and hungry rats). Electrophysiological data are discussed in terms of palatability changes and food-odor meaning.
大鼠每日上午8点至10点可获取未掺杂的合成食物，之后按照厌恶条件反射程序，在首次摄入桉叶醇味食物（EF）后注射阿扑吗啡（20毫克/千克，腹腔注射）。在第一个实验中，从第1天到第17天，于进食的前两小时测量每日食物摄入量。在第8天、第9天和第17天进食的第一或第二小时提供EF（系列B或A）。在第8天，一组大鼠进食后注射阿扑吗啡。与第8天的摄入量相比，系列A和B中第9天的平均EF摄入量显著降低，系列A中第17天的平均EF摄入量显著降低。在注射生理盐水组或未处理的对照组中未观察到EF摄入量的显著变化。在第二个实验中，植入延髓电极以慢性记录多单位二尖瓣细胞反应的大鼠在注射阿扑吗啡前接受了2小时的EF进食。分别用纯桉叶醇气味、未掺杂食物气味和EF气味刺激它们，并在饥饿和饱腹状态下进行记录。在厌恶条件反射之前，与饱腹大鼠相比，饥饿大鼠对未掺杂食物气味和EF气味的阳性反应发生率显著更高。在条件反射前后，桉叶醇气味在饥饿和饱腹大鼠中产生的反应模式相同。条件反射并未改变对未掺杂食物气味的调节反应（饥饿大鼠中仍观察到更高的阳性反应发生率），但改变了对EF气味的反应（在饱腹和饥饿大鼠中观察到相同的高阳性反应率）。从适口性变化和食物气味意义方面对电生理数据进行了讨论。
