Kohmura N, Senzaki K, Hamada S, Kai N, Yasuda R, Watanabe M, Ishii H, Yasuda M, Mishina M, Yagi T
Laboratory of Neurobiology and Behavioral Genetics, National Institute for Physiological Sciences, Myodaiji, Okazaki, Japan.
Neuron. 1998 Jun;20(6):1137-51. doi: 10.1016/s0896-6273(00)80495-x.
In mammals, neurons are highly differentiated and play distinctive functions even in the same brain region. We found a novel cadherin-related neuronal receptor (Cnr) gene family by studying Fyn-binding activity in mouse brain. CNR1 protein is located in the synaptic junction and forms a complex with Fyn. Sequence analysis of eight Cnr products of approximately 20 genes indicates that these comprise a novel cadherin family of the cadherin superfamily. The expression patterns of each member of this novel family were grossly similar to each other but restricted to subpopulations of neurons of the same type. The diversity of the Cnr family genes suggests that there are molecular mechanisms that govern highly differentiated neural networks in the mammalian CNS.
在哺乳动物中，神经元高度分化，即使在同一脑区也发挥着独特的功能。我们通过研究小鼠大脑中的Fyn结合活性，发现了一个新的钙黏蛋白相关神经元受体（Cnr）基因家族。CNR1蛋白位于突触连接处，并与Fyn形成复合物。对大约20个基因的8个Cnr产物进行序列分析表明，它们构成了钙黏蛋白超家族中的一个新的钙黏蛋白家族。这个新家族各成员的表达模式大体相似，但仅限于同一类型神经元的亚群。Cnr家族基因的多样性表明，在哺乳动物中枢神经系统中存在着调控高度分化神经网络的分子机制。
