Fu W, Duan H, Frei E, Noll M
Institute for Molecular Biology, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
Development. 1998 Aug;125(15):2943-50. doi: 10.1242/dev.125.15.2943.
We have previously shown that the sparkling gene, which like mammalian Pax2 plays an important role in eye development, is encoded by the Drosophila homolog of Pax2. Here we demonstrate that D-Pax2 also encodes the shaven function, which is crucial during bristle development. Both sv and spa alleles, previously thought to represent different genes, are mutations in two widely separated enhancers of D-Pax2. The sv function of D-Pax2 acts in at least two distinct steps of mechanosensory bristle development: the specification of the alternative fate of shaft as opposed to socket cell, and later the differentiation of the shaft cell.
我们之前已经表明，与哺乳动物Pax2一样，在眼睛发育中起重要作用的sparkling基因由Pax2的果蝇同源物编码。在这里，我们证明D-Pax2还编码shaven功能，该功能在刚毛发育过程中至关重要。之前认为代表不同基因的sv和spa等位基因，实际上是D-Pax2两个广泛分离的增强子中的突变。D-Pax2的sv功能在机械感觉刚毛发育的至少两个不同步骤中起作用：与窝细胞相对的轴的替代命运的指定，以及随后轴细胞的分化。
