Kim A C, Azim A C, Chishti A H
Laboratory of Tumor Cell Biology, St. Elizabeth's Medical Center, Tufts University School of Medicine, ACH4, 736 Cambridge Street, Boston, MA 02135, USA.
Biochim Biophys Acta. 1998 Jul 9;1398(3):382-6. doi: 10.1016/s0167-4781(98)00078-5.
Human erythroid dematin is a cytoskeletal protein capable of bundling actin filaments in vitro. The carboxyl terminal domain of dematin is homologous to the headpiece domain of villin, an actin-binding protein of the brush border cytoskeleton. Here we report the complete structure of the dematin gene located on human chromosome 8p21.1, a region frequently deleted in prostate cancer. The dematin gene is composed of 15 exons spanning approximately 15 kb. We also report two novel isoforms of dematin derived from alternative splicing of the dematin gene in the brain.
人红细胞去膜蛋白是一种细胞骨架蛋白，能够在体外将肌动蛋白丝捆绑在一起。去膜蛋白的羧基末端结构域与绒毛蛋白的头部结构域同源，绒毛蛋白是刷状缘细胞骨架的一种肌动蛋白结合蛋白。在此我们报道位于人类8号染色体p21.1上的去膜蛋白基因的完整结构，该区域在前列腺癌中经常缺失。去膜蛋白基因由15个外显子组成，跨度约为15 kb。我们还报道了在大脑中通过去膜蛋白基因的可变剪接产生的两种新型去膜蛋白异构体。
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