Rusu D, Cimpoiu C, Hodişan T
Faculty of Pharmacy, Iuliu Haţieganu University, Cluj-Napoca, Romania.
J Pharm Biomed Anal. 1998 Jul;17(3):409-13. doi: 10.1016/s0731-7085(97)00209-4.
The synthesis of the indomethacin (1H-indole-3-acetic acid, 1(4-chlorobenzoyl)-5-methoxy-2-methyl) was achieved through a new method, which reduces some stages from the previous methods. Both the structure of the finished product and the structures of the intermediaries were investigated by chromatographic methods (TLC, chromatography on column, GC-MSD) and spectroscopic methods (UV, IR, 1H-NMR, 13C-NMR). The chromatographic and spectroscopic studies proved that these had a special analytical value and they serve to control synthesis and to identify the compounds in all the stages of the process.
通过一种新方法实现了吲哚美辛（1H-吲哚-3-乙酸，1-(4-氯苯甲酰基)-5-甲氧基-2-甲基）的合成，该方法减少了之前方法中的一些步骤。采用色谱法（薄层色谱法、柱色谱法、气相色谱-质谱联用）和光谱法（紫外光谱法、红外光谱法、¹H-核磁共振光谱法、¹³C-核磁共振光谱法）对成品结构和中间体结构进行了研究。色谱和光谱研究证明这些方法具有特殊的分析价值，它们有助于控制合成过程并鉴定该过程所有阶段的化合物。
