Sampoonachot P, Bundit C, Kuhacharoen N, Peerapakorn S, Kampirapap K, Poomlek A, Bampenyu S, Tiasiri S, Rungruang S, Surasondhi S, Supanwanit S, Wiriyawipart S
Phra Pradaeng Hospital, Samut Prakan, Bangkok, Thailand.
Southeast Asian J Trop Med Public Health. 1997 Dec;28(4):803-10.
The results of ofloxacin containing combined drug regimens in the treatment of 60 multibacillary leprosy cases from January 1989 to June 1995 are reported. The objective of the trial is to compare the antileprotic property of ofloxacin and rifampicin in multibacillary leprosy patients and to study the killing rate of M. leprae by ofloxacin and rifampicin before mass treatment can be recommended. The complications and side-effects of ofloxacin and rifampicin were of a mild nature and both drugs were well tolerated. Moderate to marked clinical improvement was noticed in a short period with ofloxacin containing regimens in multibacillary leprosy patients. No persisters were detected in any of the 33 specimens (of mouse footpads) that had been obtained after treatment for 6 months. Ofloxacin if added to the currently used WHO recommended MB-MDT regimen may shorten the duration of treatment. Ofloxacin, therefore, may be considered as a suitable alternative in suspected/proven rifampicin resistant cases and where rifampicin is contraindicated. The results were evaluated on the basis of the clinical conditions, mycobactericidal effectiveness, signs of drug toxicity and side effects.
报告了1989年1月至1995年6月含氧氟沙星联合用药方案治疗60例多菌型麻风病例的结果。该试验的目的是比较氧氟沙星和利福平在多菌型麻风患者中的抗麻风特性，并在推荐大规模治疗之前研究氧氟沙星和利福平对麻风杆菌的杀灭率。氧氟沙星和利福平的并发症及副作用较轻，两种药物耐受性均良好。含氧氟沙星方案使多菌型麻风患者在短期内出现中度至显著的临床改善。治疗6个月后获得的33个（小鼠足垫）标本中均未检测到持续菌。如果将氧氟沙星添加到目前世卫组织推荐的多菌型麻风联合化疗方案中，可能会缩短治疗时间。因此，在疑似/已证实对利福平耐药的病例以及利福平禁忌的情况下，可考虑将氧氟沙星作为合适的替代药物。根据临床状况、杀分枝杆菌效力、药物毒性迹象及副作用对结果进行了评估。
