Martin E M, Pitrak D L, Pursell K J, Andersen B R, Mullane K M, Novak R M
Department of Psychiatry, University of Illinois College of Medicine, Chicago 60612, USA.
J Int Neuropsychol Soc. 1998 Jul;4(4):329-35.
Computerized reaction time (RT) tasks are sensitive measures of subclinical HIV-related mental slowing. We previously reported that nondemented HIV-seropositive patients on antiretroviral therapy at the time of testing had faster choice RTs compared to matched untreated seropositive participants. In the present study, we evaluated the performance of 163 nondemented HIV-seropositive participants on a reaction time version of the Stroop task as a function of antiretroviral status. Persons on antiretroviral therapy at the time of testing had significantly faster reaction times than untreated individuals, although treated asymptomatic participants showed significantly less Stroop interference than treated symptomatic participants. These effects could not be attributed to differences in demographic variables, disease status, substance abuse, or psychological distress. These data indicate that central information processing is faster for patients treated with antiretroviral compounds compared to untreated patients, and suggest that reaction time tasks may have significant potential utility in clinical trials of neuroprotective compounds.
计算机化反应时间（RT）任务是亚临床HIV相关精神迟缓的敏感指标。我们之前报道，在测试时接受抗逆转录病毒治疗的未患痴呆症的HIV血清阳性患者与匹配的未治疗血清阳性参与者相比，选择反应时间更快。在本研究中，我们评估了163名未患痴呆症的HIV血清阳性参与者在Stroop任务反应时间版本中的表现，该表现是抗逆转录病毒状态的函数。测试时接受抗逆转录病毒治疗的人反应时间明显快于未治疗个体，尽管接受治疗的无症状参与者的Stroop干扰明显少于接受治疗的有症状参与者。这些效应不能归因于人口统计学变量、疾病状态、药物滥用或心理困扰的差异。这些数据表明，与未治疗患者相比，接受抗逆转录病毒化合物治疗的患者中枢信息处理速度更快，并表明反应时间任务在神经保护化合物的临床试验中可能具有显著的潜在效用。
