Wong J K, Wood R E, McLean M
Department of Dentistry, Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Canada.
J Orofac Pain. 1998 Winter;12(1):52-9.
Over a 7-year period, 12 patients experienced recurrence of primary head and neck cancers preceded by severe orofacial pain. Pain began within 6 months following treatment in 10 of 12 patients and was progressive in 11 of 12 patients. Six patients died from recurrence, five within 2 years following onset of pain. No clear indication of malignant disease was evident despite clinical examination, plain radiography, magnetic resonance imaging, and computed tomography. Pain was often mistaken for denture irritation. Frequently, no area of irritation was apparent.
在7年期间，12例原发性头颈癌患者出现复发，之前伴有严重的口面部疼痛。12例患者中有10例在治疗后6个月内开始疼痛，12例患者中有11例疼痛呈进行性加重。6例患者死于复发，其中5例在疼痛发作后2年内死亡。尽管进行了临床检查、X线平片、磁共振成像和计算机断层扫描，但仍未发现明显的恶性疾病迹象。疼痛常被误诊为义齿刺激。通常，没有明显的刺激区域。
