McCarty M, Jagoda A, Fairweather P
Department of Emergency Medicine, Lincoln Medical and Mental Health Center, New York, NY, USA.
Ann Emerg Med. 1998 Jul;32(1):104-7. doi: 10.1016/s0196-0644(98)70107-6.
Hyperkalemia is a life-threatening electrolyte disturbance. The clinical presentation is most commonly related to its effects on cardiac conductivity and contractility, although weakness and respiratory compromise may occur. We describe what we believe to be the first reported case of life-threatening hyperkalemia presenting as an ascending paralysis which was associated with standard-dose trimethoprim-sulfamethoxazole therapy. The patient had mild, underlying renal disease which predisposed him to develop hyperkalemia. This case underscores the need to use caution in prescribing trimethoprim to such patients.
高钾血症是一种危及生命的电解质紊乱。其临床表现最常见的是与对心脏传导性和收缩性的影响有关，尽管也可能出现肌无力和呼吸功能不全。我们描述了我们认为是首例报告的以进行性麻痹为表现的危及生命的高钾血症病例，该病例与标准剂量的甲氧苄啶 - 磺胺甲恶唑治疗有关。患者有轻度的基础肾病，这使他易发生高钾血症。该病例强调了在此类患者中开具甲氧苄啶时需谨慎的必要性。
