Wasfi I A, Hadi A A, Alkatheeri N A, Barezaiq I M, ElGhazali M, Boni N S, Zorob O
Camelracing Forensic Laboratory, Forensic Science Laboratory, Abu Dhabi, United Arab Emirates.
J Chromatogr B Biomed Sci Appl. 1998 May 29;709(2):209-15. doi: 10.1016/s0378-4347(98)00057-7.
A flunixin metabolite, a hydroxylated product, has been identified in camel urine and plasma samples using gas chromatography-mass spectrometry (GC-MS) and GC-MS-MS in the electron impact and chemical ionization modes. Its major fragmentation pattern has been verified by GC-MS-MS in daughter ion and parent ion scan modes. The method could detect flunixin and its metabolite in camel urine after a single intravenous dose of 2.2 mg of flunixin/kg body weight for 96 and 48 h, respectively, which increases the reliability of antidoping control analysis.
已使用气相色谱 - 质谱联用仪（GC - MS）以及在电子轰击和化学电离模式下的GC - MS - MS，在骆驼尿液和血浆样本中鉴定出氟尼辛的一种代谢物，即一种羟基化产物。其主要裂解模式已通过在子离子和母离子扫描模式下的GC - MS - MS得到验证。该方法在分别单次静脉注射2.2毫克氟尼辛/千克体重后96小时和48小时，能够检测骆驼尿液中的氟尼辛及其代谢物，这提高了反兴奋剂控制分析的可靠性。
