Pislaru S V, Pislaru C, Zhu X, Arnout J, Stassen T, Vanhove P, Herbert J M, Meuleman D G, Van de Werf F
Department of Cardiology, University Hospitals Leuven, Belgium.
Thromb Haemost. 1998 Jun;79(6):1130-5.
The effects on alteplase-induced thrombolysis of the synthetic ATIII-binding pentasaccharide SR90107A/ORG 31540 (synthetic pentasaccharide, SP) and of standard heparin (SH) were compared in a copper coil model of coronary artery thrombosis in 6 groups of 10 dogs. After 1 h of occlusion, all animals received intravenously alteplase and aspirin, and were randomly assigned to a 2 h infusion of either saline, or one of two doses of SH (100 IU/kg bolus plus 50 IU/kg/h infusion, or 200 IU/kg bolus plus 100 IU/kg/h infusion), or one of three doses of SP (100 nmol/kg bolus plus 50 nmol/kg/h infusion, 200 nmol/kg bolus plus 100 nmol/kg/h infusion, or 400 nmol/kg bolus plus 200 nmol/kg/h infusion). Coronary angiography was performed every 10 min for 4 h. Appropriate doses of SP and SH enhanced alteplase-induced thrombolysis to a similar extent. In contrast, SP was devoid of any anti-IIa activity or aPTT prolongation.
在6组每组10只犬的冠状动脉血栓形成铜线圈模型中，比较了合成的抗凝血酶III（ATIII）结合五糖SR90107A/ORG 31540（合成五糖，SP）和标准肝素（SH）对阿替普酶诱导溶栓的影响。闭塞1小时后，所有动物静脉注射阿替普酶和阿司匹林，并随机分配接受2小时的生理盐水输注，或两种剂量的SH之一（100 IU/kg推注加50 IU/kg/h输注，或200 IU/kg推注加100 IU/kg/h输注），或三种剂量的SP之一（100 nmol/kg推注加50 nmol/kg/h输注，200 nmol/kg推注加100 nmol/kg/h输注，或400 nmol/kg推注加200 nmol/kg/h输注）。在4小时内每10分钟进行一次冠状动脉造影。适当剂量的SP和SH在相似程度上增强了阿替普酶诱导的溶栓作用。相比之下，SP没有任何抗IIa活性或活化部分凝血活酶时间（aPTT）延长。
