Futami H, Kodaira M, Furuta T, Hanai H, Kaneko E
First Department of Medicine, Hamamatsu University of Medicine, Japan.
J Gastroenterol. 1998 Jun;33(3):408-11. doi: 10.1007/s005350050104.
A 32-year-old woman with ulcerative colitis had a relapsed of pyoderma gangrenosum during puerperium. Both the pyoderma gangrenosum and ulcerative colitis had been well controlled with oral prednisolone, but ulcerative colitis relapsed in pregnancy, and pyoderma gangrenosum relapsed in the puerperium. The pyoderma gangrenosum responded to methylprednisolone pulse therapy initially, but relapsed when prednisolone was tapered. A second trial of pulse therapy combined with cyclosporine resulted in complete remission of the pyoderma gangrenosum, and no recurrence was recognized after prednisolone was tapered. This is a very rare case of successful treatment with methylprednisolone pulse therapy combined with cyclosporine for pyoderma gangrenosum complicating ulcerative colitis.
一名32岁患有溃疡性结肠炎的女性在产褥期发生坏疽性脓皮病复发。坏疽性脓皮病和溃疡性结肠炎此前均通过口服泼尼松龙得到良好控制，但溃疡性结肠炎在孕期复发，坏疽性脓皮病在产褥期复发。坏疽性脓皮病最初对甲泼尼龙冲击疗法有反应，但在泼尼松龙减量时复发。第二次冲击疗法联合环孢素的试验使坏疽性脓皮病完全缓解，在泼尼松龙减量后未再复发。这是1例采用甲泼尼龙冲击疗法联合环孢素成功治疗坏疽性脓皮病合并溃疡性结肠炎的非常罕见的病例。
