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[二氧化碳激光治疗喉乳头状瘤病]

[CO2 laser treatment in laryngeal papillomatosis].

作者信息

Pia F, Aluffi P, Policarpo M, Pisani P

机构信息

Clinica ORL, Università di Torino.

出版信息

Acta Otorhinolaryngol Ital. 1997 Dec;17(6):425-9.

PMID:9658628
Abstract

Laryngeal papillomatosis is a rare, unpredictable pathology which often recurs. Although several forms of surgery have been suggested for this pathology, CO2 laser surgery is the treatment of choice. This paper presents 30 cases of laryngeal papillomatosis, 12 of which arose in infancy, all treated by dissection and/or CO2 laser vaporization. The treatments were performed in one or more stages depending on the site and appearance of the lesions. Special care must be taken to preserve the anatomical integrity when a papillomatosis must be removed from the glottic area. The average number of surgical procedures per patient proved greater in multifocal vs. unifocal forms (4.7 vs. 1.6) and in children vs. adults (4.9 vs. 3.7). In four patients the pathology followed a neoplastic evolution. Today 57% of the subjects treated (17) are in clinical remission after an average 17 month follow-up. CO2 laser endoscopic microsurgery is presently the most suitable method for treating laryngeal papillomatosis although the biological features of this diseases often make treatment difficult.

摘要

喉乳头状瘤病是一种罕见的、不可预测的且常复发的病理状况。尽管针对这种病理状况已提出多种手术方式,但二氧化碳激光手术是首选治疗方法。本文介绍了30例喉乳头状瘤病病例,其中12例在婴儿期发病,均采用剥离和/或二氧化碳激光汽化治疗。根据病变部位和外观,治疗分一个或多个阶段进行。当必须从声门区切除乳头状瘤病时,必须特别注意保持解剖结构的完整性。多灶性与单灶性形式相比(4.7比1.6)以及儿童与成人相比(4.9比3.7),每位患者的平均手术次数更多。4例患者的病理情况呈肿瘤性演变。目前,经过平均17个月的随访,57%(17例)接受治疗的患者处于临床缓解状态。尽管这种疾病的生物学特性常常使治疗困难,但二氧化碳激光内镜显微手术目前是治疗喉乳头状瘤病最合适的方法。

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