酶替代疗法可降低戈谢病中的高球蛋白血症。
Enzyme replacement therapy decreases hypergammaglobulinemia in Gaucher's disease.
作者信息
Deibener J, Kaminsky P, Jacob C, Dousset B, Klein M, Duc M
出版信息
Haematologica. 1998 May;83(5):479-80.
PMID:9658738
Abstract
We report the effects of enzyme replacement therapy in a patient with Gaucher's disease associated with a monoclonal gammopathy. Alglucerase induces a linear decline in immunoglobulin and beta 2-microglobulin levels. This observation suggests that this treatment decreases the chronic antigenic stimulation commonly found in Gaucher's disease.
摘要
我们报告了酶替代疗法对一名患有与单克隆丙种球蛋白病相关的戈谢病患者的疗效。阿糖苷酶可使免疫球蛋白和β2-微球蛋白水平呈线性下降。这一观察结果表明，这种治疗可减少戈谢病中常见的慢性抗原刺激。
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