细胞角蛋白19片段作为肺癌的标志物。

Cyfra 21-1 as a marker of lung cancer.

作者信息

Kinoshita M, Watanabe H, Ichiki M, Sumita S, Okubo Y, Matsunami M, Furuno H, Shiraishi T, Rikimaru T, Oizumi K

机构信息

Department of Medicine, Kurume University School of Medicine, Japan.

出版信息

Kurume Med J. 1998;45(1):7-9. doi: 10.2739/kurumemedj.45.7.

DOI:10.2739/kurumemedj.45.7

PMID:9658744

Abstract

The utility of cytokeratin fragment (Cyfra) 21-1, a new tumor marker, was investigated in 100 patients with lung cancer. Sandwich enzyme immunoassay detected Cyfra 21-1 in the sera of 60% of patients. Sensitivity of this marker was especially high (86.4%) for squamous cell carcinoma, exceeding that of a similar marker, squamous cell carcinoma antigen (SCC, 54.5%). In contrast, sensitivity of Cyfra 21-1 was relatively low for adenocarcinoma (52.6%) and for small cell carcinoma (50%). We conclude that Cyfra 21-1 is of value in diagnosis of lung cancer, particularly squamous cell carcinoma.

摘要

对100例肺癌患者研究了一种新型肿瘤标志物细胞角蛋白片段（Cyfra）21-1的效用。夹心酶免疫测定法在60%患者的血清中检测到了Cyfra 21-1。该标志物对鳞状细胞癌的敏感性特别高（86.4%），超过了类似标志物鳞状细胞癌抗原（SCC，54.5%）。相比之下，Cyfra 21-1对腺癌（52.6%）和小细胞癌（50%）的敏感性相对较低。我们得出结论，Cyfra 21-1在肺癌诊断中具有价值，尤其是对鳞状细胞癌。