Rogala B
Wiad Lek. 1998;51(3-4):117-21.
The article is the review of the data from literature concerning the new role of theophilline in the management of asthma and chronic bronchoobturative pulmonary disease. Theophilline has been widely used to treat asthma and COPD patients worldwide and is classified as a bronchodilatator, although there is increasing evidence that it has antiinflammatory activity and enhances immunomodulatory effects. The latter is therapeutically relevant to markedly lower serum concentration (even < 10 micrograms/ml) than this required for bronchodilatation. That is particularly clinically important because significant adverse effects have been seen only in the case of doses greater than 10 micrograms/ml.
本文是一篇文献综述，内容涉及茶碱在哮喘和慢性阻塞性肺疾病治疗中的新作用。在全球范围内，茶碱已被广泛用于治疗哮喘和慢性阻塞性肺疾病患者，并且被归类为支气管扩张剂，尽管越来越多的证据表明它具有抗炎活性并能增强免疫调节作用。后者在治疗方面具有相关性，因为其血清浓度明显低于支气管扩张所需的浓度（甚至<10微克/毫升）。这在临床上尤为重要，因为仅在剂量大于10微克/毫升时才会出现明显的不良反应。
