Hall A V, Solanki K K, Vinjamuri S, Britton K E, Das S S
Department of Medical Microbiology, St Bartholomew's Hospital, West Smithfield, London, UK.
J Clin Pathol. 1998 Mar;51(3):215-9. doi: 10.1136/jcp.51.3.215.
To determine the sensitivity and specificity of 99mTc-Infecton (Infecton), a novel ciprofloxacin based imaging agent, in detecting sites of infection.
Ninety patients thought to be suffering from a variety of infections were administered 300-400 MBq of Infecton intravenously. Whole body images were taken one and four hours later. Appropriate specimens were taken for microbiological investigations. Statistical analysis was performed using a computer statistical package.
Ninety eight Infecton images were produced. Forty one of these were positive, including three false positives, where the patients had non-infective conditions. Fifty seven negative images were obtained, of which 41 were true negatives and 16 were false negatives, having definite evidence of infection. Thus, Infecton imaging has a sensitivity of 70.3% and a specificity of 93.1% for detecting infective foci. The positive and negative predictive values were 92.6% and 71.9%, respectively.
Infecton imaging is a new diagnostic tool that is specific for detecting sites of bacterial infection in the body. The high positive predictive value displayed by the technique is clinically important because a positive image strongly supports a diagnosis of bacterial infection. A negative result does not rule out an infection, and may be a result of previous or current antibiotic treatment and/or infection with organisms that do not take up Infecton. Infecton imaging has major advantages over well established imaging techniques, including radiolabelled leucocytes, and may prove to be a superior method for localising bacterial infections.
确定一种新型的基于环丙沙星的显像剂99mTc-感染素（Infecton）在检测感染部位方面的敏感性和特异性。
对90例被认为患有各种感染的患者静脉注射300 - 400MBq的Infecton。1小时和4小时后进行全身显像。采集适当的标本进行微生物学检查。使用计算机统计软件包进行统计分析。
共生成98张Infecton图像。其中41张为阳性，包括3例假阳性，这些患者患有非感染性疾病。获得57张阴性图像，其中41张为真阴性，16张为假阴性，这些患者有明确的感染证据。因此，Infecton显像检测感染灶的敏感性为70.3%，特异性为93.1%。阳性和阴性预测值分别为92.6%和71.9%。
Infecton显像是一种用于检测体内细菌感染部位的新型诊断工具。该技术显示出的高阳性预测值在临床上具有重要意义，因为阳性图像强烈支持细菌感染的诊断。阴性结果不能排除感染，可能是先前或当前抗生素治疗和/或感染了不摄取Infecton的生物体的结果。Infecton显像相对于成熟的显像技术（包括放射性标记白细胞）具有主要优势，可能被证明是定位细菌感染的一种更优越的方法。
