Morgan J R, Williams L A, Howard C B
Br J Radiol. 1985 Jan;58(685):35-9. doi: 10.1259/0007-1285-58-685-35.
Negatively charged phospholipid liposomes were labelled with technetium 99m and used as a radioisotopic tracer to detect focal inflammatory lesions in deep-seated sepsis and rheumatoid arthritis. Patients received an intravenous injection of the radiolabelled liposome preparation and were submitted to scintigraphy on the following day. Both the human volunteer and patients showed uptake in liver and spleen but no radioactivity was observed associated with the intestines. Radioactive uptake was visualised in infected prosthetic joints, tubo-ovarian abscess and osteomyelitis. In a patient with active rheumatoid arthritis radioactive uptake was confined to clinically affected joints. The preliminary findings suggest potential for technetium labelled liposomes as a diagnostic tracer.
带负电荷的磷脂脂质体用锝99m进行标记，并用作放射性同位素示踪剂，以检测深部脓毒症和类风湿性关节炎中的局灶性炎症病变。患者接受放射性标记脂质体制剂的静脉注射，并于次日进行闪烁扫描。人类志愿者和患者均显示肝脏和脾脏有摄取，但未观察到与肠道相关的放射性。在感染的人工关节、输卵管卵巢脓肿和骨髓炎中可见放射性摄取。在一名活动性类风湿性关节炎患者中，放射性摄取局限于临床受累关节。初步研究结果表明，锝标记脂质体作为诊断示踪剂具有潜力。
