Pietrzik K, Brönstrup A
Department of Pathophysiology of Nutrition, University of Bonn, Germany.
Arch Latinoam Nutr. 1997 Jun;47(2 Suppl 1):9-12.
Recently, elevated homocysteine blood concentrations have been identified as an independent risk factor for the development of atherosclerotic lesions. The amino acid homocysteine is metabolized in the human body involving the vitamins folic acid, B12 and B6 as essential cofactors and coenzymes, respectively. There is an inverse relationship between the status of the relevant B-vitamins and the homocysteine blood concentration. Supplementation of these vitamins results in a significant reduction of the homocysteine level. Nutritive amounts seem to be sufficient to obtain this reduction, even in the case of elevated homocysteine levels.
最近，血液中同型半胱氨酸浓度升高已被确定为动脉粥样硬化病变发展的独立危险因素。氨基酸同型半胱氨酸在人体中代谢，分别涉及维生素叶酸、维生素B12和维生素B6作为必需的辅因子和辅酶。相关B族维生素的状态与血液中同型半胱氨酸浓度呈负相关。补充这些维生素会使同型半胱氨酸水平显著降低。即使在同型半胱氨酸水平升高的情况下，营养剂量似乎也足以实现这种降低。
