异烟肼与多种血管扩张剂之间的相互作用：脑内γ-氨基丁酸减少的作用
Interaction between isoniazid and diverse vasodilators: role of decreased cerebral GABA.
作者信息
de los Angeles Sánchez-Salvatori M, Ríos C, Vidrio H
机构信息
Department of Pharmacology, School of Medicine, National University of Mexico.
出版信息
Cardiovasc Res. 1998 Mar;37(3):748-55. doi: 10.1016/s0008-6363(97)00264-2.
OBJECTIVE
To determine if the interaction between isoniazid and hydralazine, consisting of increased hypotension accompanied by bradycardia, occurs with other vasodilators.
METHODS
Blood pressure and heart rate responses to a number of vasodilators were determined in rats under chloralose-urethane, pretreated or not with 250 mg/kg of isoniazid. The influence of this dose of isoniazid on GABA levels in the hypothalamus and pons-medulla was assessed in other groups of rats.
RESULTS
Increased hypotension and bradycardia following i.p. isoniazid were observed with dipyridamole, prazosin, pinacidil and hydralazine given i.v. Bradycardia without increased hypotension appeared with papaverine and verapamil, while increased hypotension with unchanged heart rate was observed with minoxidil and captopril. Isoniazid decreased GABA in the hypothalamus and pons-medulla.
CONCLUSIONS
At the high dose used, isoniazid interacts with various vasodilators, irrespective of their mechanism of action. The interaction could be due to the influence of the drug on GABA levels at cardiovascular regulatory sites.
目的
确定异烟肼与肼屈嗪之间相互作用（表现为低血压加重并伴有心动过缓）是否也会与其他血管扩张剂发生。
方法
在水合氯醛 - 乌拉坦麻醉的大鼠中，测定给予或不给予250mg/kg异烟肼预处理后，多种血管扩张剂对血压和心率的反应。在其他几组大鼠中评估该剂量异烟肼对下丘脑和脑桥 - 延髓中γ-氨基丁酸（GABA）水平的影响。
结果
静脉注射双嘧达莫、哌唑嗪、匹那地尔和肼屈嗪后，腹腔注射异烟肼会导致低血压和心动过缓加重。静脉注射罂粟碱和维拉帕米后出现心动过缓但无低血压加重，而静脉注射米诺地尔和卡托普利后出现低血压加重但心率不变。异烟肼会降低下丘脑和脑桥 - 延髓中的GABA水平。
结论
在所用的高剂量下，异烟肼与各种血管扩张剂相互作用，无论其作用机制如何。这种相互作用可能是由于该药物对心血管调节部位GABA水平的影响。
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