[Changes in biogenic amines and connective tissue in the process of chemical carcinogenesis].

On two models of chemically induced tumors (cancer of the mammary gland and subcutaneous sarcoma) in rats the author has demonstrated the kinetics of biogenic amines transformations in the organism and their association with the developed structural-functional disorders in the connective tissue elements. It was found that the activity of connective tissue cells determined by the presence in them of such enzymes as nonspecific esterase, lipase and monoaminoxidase is directly dependent on the status of the intestinal enterochromaffin apparatus and the adrenal medulla and also on the presence of serotonin in connective tissue cells. The appearance of di-and polyamines in the pretumor period and their increase in the tumor period in conncective tissue noncellular structures indicate the enhancement of degeneration of these structures, while the presence of these substances in connective tissue cells evidences the suppression of their specific functions. It is believed that the source of production of di-and polyamines in the organism under tumor development is protein formations of noncellular structures of the connective tissue subjected to deorganization and destruction.