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[肺炎球菌性心内膜炎复发了吗?]

[Did pneumococcal endocarditis come back?].

作者信息

Lindberg J A, Prag J

机构信息

Viborg Sygehus, klinisk mikrobiologisk afdeling.

出版信息

Ugeskr Laeger. 1998 Jun 29;160(27):4047-9.

PMID:9659832
Abstract

Endocarditis caused by pneumococci represents 1-5% of all cases of endocarditis according to publications from different western countries. Necropsy studies show frequencies of up to 14% of all cases of endocarditis. It usually occurs as a complication to a pneumococcal pneumonia but other foci might be seen. Concomitant meningitis is seen in 20-85% of patients suffering from pneumococcal endocarditis. By knowing this disease entity there is a good possibility for treatment with antibiotics and valve replacement, but if overlooked the mortality is high. The frequency of pneumococcal endocarditis might be underestimated. Careful stethoscopic examination for heart murmurs should be a part of the clinical examination in case of invasive pneumococcal disease, especially with concomitant meningitis. Since bacteriaemia due to pneumococci is diagnosed with increasing frequency in many Northern European countries, special attention should be paid to pneumococcal endocarditis. The literature is reviewed with reference to pathology, pathogenesis, frequency, clinical presentation, diagnosis, treatment and prognosis.

摘要

根据不同西方国家的出版物,肺炎球菌引起的心内膜炎占所有心内膜炎病例的1%-5%。尸检研究显示,在所有心内膜炎病例中,其发生率高达14%。它通常作为肺炎球菌肺炎的并发症出现,但也可能出现其他病灶。20%-85%的肺炎球菌性心内膜炎患者会并发脑膜炎。了解这种疾病实体后,使用抗生素和进行瓣膜置换治疗有很大可能性,但如果被忽视,死亡率很高。肺炎球菌性心内膜炎的发生率可能被低估。对于侵袭性肺炎球菌疾病,尤其是伴有脑膜炎的情况,仔细的听诊检查心脏杂音应作为临床检查的一部分。由于在许多北欧国家,肺炎球菌引起的菌血症诊断频率越来越高,因此应特别关注肺炎球菌性心内膜炎。本文参考病理学、发病机制、发生率、临床表现、诊断、治疗和预后对相关文献进行了综述。

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