Fujino T, Ichikawa H, Fried B
Department of Biology, Faculty of Science, Yamagata University, Japan.
Parasitol Res. 1998 Jun;84(6):519-21. doi: 10.1007/s004360050440.
C3H/HeN mice were infected with Echinostoma trivolvis metacercariae on day 0, given intramuscular injections of the immunosuppressive agent FK506 daily for 5 or 7 days, and necropsied on days 5, 8, 12, 15, 20, and 30 postinfection (p.i.). Control mice were infected with the echinostomes but were not treated with FK506. A significant reduction in mastocytosis was seen from day 12 to day 15 p.i. in the treated group. No reduction was observed in numbers of goblet cells and eosinophils in the treated group. The number of white blood cells was lower in the treated mice than in the controls. No significant difference in the optical density values of immunoglobulins appeared in control versus treated mice. Treatment with FK506 did not delay worm expulsion markedly, probably because the drug did not suppress goblet-cell hyperplasia. Increased mucus production associated with goblet-cell hyperplasia is primarily involved in the expulsion of E. trivolvis in murine hosts.
在第0天，将三歧棘口吸虫尾蚴感染C3H/HeN小鼠，每天给小鼠肌肉注射免疫抑制剂FK506，持续5天或7天，并在感染后第5、8、12、15、20和30天进行尸检。对照小鼠感染了棘口吸虫，但未用FK506治疗。在治疗组中，从感染后第12天到第15天观察到肥大细胞增多症显著减少。治疗组杯状细胞和嗜酸性粒细胞数量未减少。治疗组小鼠的白细胞数量低于对照组。对照小鼠和治疗小鼠之间免疫球蛋白的光密度值没有显著差异。用FK506治疗并没有显著延迟蠕虫排出，可能是因为该药物没有抑制杯状细胞增生。与杯状细胞增生相关的黏液分泌增加主要参与了小鼠宿主中三歧棘口吸虫的排出。
