Yates W R, Cadoret R J, Troughton E P, Stewart M, Giunta T S
Department of Psychiatry, University of Oklahoma College of Medicine, Tulsa Campus, 74129-1077, USA.
Alcohol Clin Exp Res. 1998 Jun;22(4):914-20.
The objective of this study is to examine the effect of fetal alcohol exposure on later substance dependence using an adoption study method.
One hundred ninety-seven adoptees were interviewed for substance abuse disorders, including nicotine, alcohol, and drug dependence. Twenty-one adoptees had mothers who drank during pregnancy. Adoptees with fetal alcohol exposure were compared with those without fetal alcohol exposure for symptoms of adult nicotine, alcohol, and drug dependence.
Adoptee symptom counts for alcohol, drug, and nicotine dependence were higher for those exposed to alcohol in utero. The effect of fetal alcohol exposure remained after controlling for gender, biological parent alcohol dependence diagnosis, birth weight, gestational age and other environmental variables.
Fetal alcohol exposure may produce increased risk for later nicotine, alcohol, and drug dependence. Possible effects of fetal alcohol exposure on development of adult substance use patterns needs attention in genetic studies of substance abuse.
本研究的目的是采用收养研究方法，探讨胎儿酒精暴露对日后物质依赖的影响。
对197名被收养者进行了关于物质滥用障碍的访谈，包括尼古丁、酒精和药物依赖。21名被收养者的母亲在孕期饮酒。将有胎儿酒精暴露的被收养者与无胎儿酒精暴露的被收养者在成人尼古丁、酒精和药物依赖症状方面进行比较。
子宫内接触酒精的被收养者在酒精、药物和尼古丁依赖方面的症状计数更高。在控制了性别、亲生父母酒精依赖诊断、出生体重、孕周和其他环境变量后，胎儿酒精暴露的影响依然存在。
胎儿酒精暴露可能会增加日后尼古丁、酒精和药物依赖的风险。胎儿酒精暴露对成人物质使用模式发展的潜在影响在药物滥用的遗传学研究中需要引起关注。
Zotero 插件