Shames D M, Korobkin M
J Nucl Med. 1976 Oct;17(10):876-9.
To determine whether externally monitored early renal uptake of 131I-hippurate is proportional to renal blood flow, the renal uptake of 131I-hippurate at 1--2 min after injection was compared with the renal accumulation of radioactive carbonized microspheres in dogs. A renal artery catheter equipped with a balloon was used to decrease renal blood flow unilaterally. One minute after the intravenous injection of 100 muCi of 131I-hippurate, about 1 muCi of either 85Sr- or 98Nb-labeled carbon microspheres was injected into the left ventricle. Radioactivity was measured over both kidneys. The total radioactivity within each kidney region of interest was corrected for background and integrated over the 1--2 min after injection. Thirteen measurements of relative renal blood flow were made for seven dogs. The dogs were then killed and both kidneys were excised and counted for the radioactivity of the microspheres. The 1--2-min relative renal uptake of 131I-hippurate correlated well with relative microsphere uptake, suggesting that relative renal blood flow can be simply determined from the external measurement of renal uptake of 131I-hippurate.
为了确定131I-马尿酸盐的早期肾脏摄取量通过外部监测是否与肾血流量成正比，将注射后1至2分钟时131I-马尿酸盐的肾脏摄取量与狗体内放射性碳化微球的肾脏蓄积量进行了比较。使用配备气囊的肾动脉导管单侧减少肾血流量。静脉注射100μCi的131I-马尿酸盐1分钟后，将约1μCi的85Sr或98Nb标记的碳微球注入左心室。测量双侧肾脏的放射性。对每个肾脏感兴趣区域内的总放射性进行本底校正，并在注射后1至2分钟内进行积分。对7只狗进行了13次相对肾血流量的测量。然后处死这些狗，切除双侧肾脏并计数微球的放射性。131I-马尿酸盐1至2分钟的相对肾脏摄取量与微球相对摄取量相关性良好，这表明可以通过外部测量131I-马尿酸盐的肾脏摄取量来简单地确定相对肾血流量。
