Schiebe M E, Hoffmann W, Belka C, Bamberg M
Department of Radiotherapy, University of Tübingen, Germany.
Anticancer Drugs. 1998 Jun;9(5):433-5. doi: 10.1097/00001813-199806000-00010.
In rare cases mitomycin C (MMC) may induce cancer-associated hemolytic uremic syndrome, which is characterized by hemolytic anemia, thrombocytopenia and progressive renal failure. Treatment possibilities of this multisystem disease up to now remain disappointing. We report a case of MMC-related hemolytic uremic syndrome, and discuss the etiologic parameters, clinical aspects, prognosis and treatment modalities of this severe syndrome.
在罕见情况下，丝裂霉素C（MMC）可能诱发与癌症相关的溶血性尿毒症综合征，其特征为溶血性贫血、血小板减少和进行性肾衰竭。迄今为止，这种多系统疾病的治疗可能性仍然令人失望。我们报告一例与MMC相关的溶血性尿毒症综合征病例，并讨论该严重综合征的病因参数、临床方面、预后和治疗方式。
