Albas A, Pardo P E, Gomes A A, Bernardi F, Ito F H
Instituto Biológico, Faculdade de Ciências Agrárias, Universidade do Oeste Paulista, SP, Brasil.
Rev Soc Bras Med Trop. 1998 Jul-Aug;31(4):367-71. doi: 10.1590/s0037-86821998000400006.
Humoral immune response using inactivated rabies vaccine was studied in 35 nelore cross-bred bovines of western region of São Paulo state. Ninety days after vaccination, 13 (92.8%) animals presented titers > or = 0.5 IU/ml, through mouse neutralization test. After 180 days, 9 (64.3%) sera showed titers > or = 0.5 IU/ml, after 270 days, only one (7.1%) showed a titer of 0.51 IU/ml, and after 360 days, all animals showed titers < 0.5 IU/ml. Group of animals receiving booster dose 30 days after vaccination presented, two months after, all with titers > 0.5 IU/ml. At 180 days, 17 (80.9%) sera presented titers > 0.5 IU/ml; at 270 days, 15 (71.4%), with titers > or = 0.5 IU/ml and at 360 days, 4 (19.0%), with titers > or = 0.5 IU/ml. Booster-dose ensured high levels of neutralizing antibodies for at least three months, and 240 days after revaccination, 71.4% of animals were found with titers > or = 0.5 IU/ml.
在圣保罗州西部地区的35头内洛雷杂交牛中研究了使用灭活狂犬病疫苗后的体液免疫反应。接种疫苗90天后，通过小鼠中和试验，13头（92.8%）动物的滴度≥0.5 IU/ml。180天后，9份（64.3%）血清的滴度≥0.5 IU/ml，270天后，只有1份（7.1%）的滴度为0.51 IU/ml，360天后，所有动物的滴度均<0.5 IU/ml。在接种疫苗30天后接受加强剂量的动物组，两个月后所有动物的滴度均>0.5 IU/ml。在180天时，17份（80.9%）血清的滴度>0.5 IU/ml；在270天时，15份（71.4%）的滴度≥0.5 IU/ml，在360天时，4份（19.0%）的滴度≥0.5 IU/ml。加强剂量确保了至少三个月的高滴度中和抗体水平，再次接种疫苗240天后，发现71.4%的动物滴度≥0.5 IU/ml。
