Monsalve M V, Frota-Pessoa O, Campos A M, Sette H
J Toxicol Environ Health. 1976 Jul;1(6):1023-6. doi: 10.1080/15287397609529405.
Blood samples from 24 patients infested with Schistosoma mansoni were drawn immediately before and 2 days after the administration of a single therapeutic dose of 12-15 mg/kg oral oxaminiquine. Two-day lymphocyte cultures were obtained and about 100 mitoses from each blood sample were analyzed for chromosome aberrations. No significant differences were observed between the "before" and "after" cultures in the frequencies of aberrations resulting from spindle, chromatidic, or chromosome events. It is concluded that there is no reason to fear harmful effects on the chromosomes of patients from treatment with oxaminiquine.
从24名感染曼氏血吸虫的患者身上采集血样，分别在口服单剂量12 - 15毫克/千克奥沙米喹治疗前和治疗后2天采集。获得了两天的淋巴细胞培养物，并对每个血样中约100个有丝分裂进行染色体畸变分析。在纺锤体、染色单体或染色体事件导致的畸变频率方面，“治疗前”和“治疗后”的培养物之间未观察到显著差异。得出的结论是，没有理由担心奥沙米喹治疗会对患者染色体产生有害影响。
