[利用抗人免疫球蛋白抗血清研究动物与人免疫球蛋白之间的抗原关系]
[Study of the antigenic relationship between animal and human immunoglobulins using antisera to human immunoglobulins].
作者信息
Chernokhvostova E V, German G P, Malukas E Z, Borovik R V, Liubinskaia M M
出版信息
Zh Mikrobiol Epidemiol Immunobiol. 1978 Feb(2):41-5.
Cross-reactivity of monospecific antisera to human immunoglobulins with animal sera of 10 species was studied by immunoelectrophoresis and radial immunodiffusion. Antisera to IgG were shown to reveal IgG of all the species studied, antisera to IgM and especially to IgA cross reacted less extensively. The greatest number of cross reactions were given by the antisera obtained as a result of hyperimmunization. Hyperimmune monospecific antisera to human IgG, IgA, and IgM can be used for the identification of animal immunoglobulins during their isolation from the sera and for their quantitation by radial immunodiffusion.
通过免疫电泳和放射免疫扩散研究了单特异性抗人免疫球蛋白血清与10种动物血清的交叉反应性。结果显示，抗IgG血清可识别所有研究物种的IgG，抗IgM血清尤其是抗IgA血清的交叉反应范围较小。超免疫产生的血清产生的交叉反应最多。人IgG、IgA和IgM的超免疫单特异性抗血清可用于从血清中分离动物免疫球蛋白时的鉴定，以及通过放射免疫扩散进行定量。
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