Abe Y, Kishimoto T, Yamamoto K
Jpn Circ J. 1976 Aug;40(8):935-43. doi: 10.1253/jcj.40.935.
The present investigation examined the relationship between renin release and renal autoregulation of blood flow in the anesthetized dogs. A reduction in renal arterial pressure from control pressure to 100mmHg changed neither the flow rates of all cortex zones nor renin secretion. Further reductions of renal arterial pressure to 70mmHg and 50mmHg resulted in a significant increase of renin secretion and a decrease of blood flow in the outer cortex. Intrarenal arterial infusion of acethylcholine abolished an autoregulation of blood flow and pressure reduction to 100mmHg during acetylcholine infusion resulted in a marked increase of renin secretion without any further change in afferent arteriolar resistance. Intrarenal arterial infusion of norepinephrine at a control pressure increased a renin release. However, norepinephrine infusion at reduced pressure suppressed the renin release with recovery a vascular resistance to the control level. These results suggest that the changes in the degree of blood flow and pressure in the renal afferent arterioles are not essential for the renin release, but renin release by the pressure reduction might be related to the autoregulatory capapcity of afferent arterioles in the outer cortex.
本研究考察了麻醉犬肾素释放与肾血流自身调节之间的关系。肾动脉压从对照压力降至100mmHg时，所有皮质区的血流速率和肾素分泌均未改变。肾动脉压进一步降至70mmHg和50mmHg时，肾素分泌显著增加，外皮质血流减少。肾内动脉注入乙酰胆碱可消除血流自身调节，注入乙酰胆碱期间压力降至100mmHg会导致肾素分泌显著增加，而传入小动脉阻力无进一步变化。在对照压力下肾内动脉注入去甲肾上腺素会增加肾素释放。然而，在减压状态下注入去甲肾上腺素会抑制肾素释放，同时血管阻力恢复到对照水平。这些结果表明，肾传入小动脉血流和压力程度的变化对肾素释放并非至关重要，但减压引起的肾素释放可能与外皮质传入小动脉的自身调节能力有关。
