Finke R, Gross R, Hackenthal E, Huber J, Kirchheim H R
Pflugers Arch. 1983 Oct;399(2):102-10. doi: 10.1007/BF00663904.
The effect of varying renal artery pressure between 160 and 40 mm Hg on renal blood flow and renin release was studied in seven conscious foxhounds under beta-adrenergic blockade receiving a normal sodium diet (4.1 mmol/kg/day). Pressure was either increased by bilateral common carotid occlusion or reduced in steps and maintained constant by a control-system using an inflatable renal artery cuff. Carotid occlusion itself had no influence on renal blood flow and renin release when renal artery pressure was kept constant and the beta-receptors in the kidney were blocked. Between 160 mm Hg and resting pressure there was no change in renal blood flow; between resting blood pressure and the lower limit of autoregulation (average 63.9 mm Hg) renal blood flow increased slightly (average 7%) indicating a high efficiency of renal blood flow autoregulation. The relationship between renal artery pressure and renin release could be approximated by two linear sections: a low sensitivity to a pressure change (average slope: -0.69 +/- 0.26 ng AI/min/mm Hg) was found above a threshold pressure (average: 89.8 +/- 3.3 mm Hg) and a high sensitivity to a pressure change (average slope: -64.4 +/- 20.8 ng AI/min/mm Hg) was observed between threshold pressure and 60 mm Hg. There was no further increase of renin release between 60 and 40 mm Hg.(ABSTRACT TRUNCATED AT 250 WORDS)
在七只清醒的猎狐犬中，研究了在接受正常钠饮食（4.1 mmol/kg/天）且处于β-肾上腺素能阻滞状态下，肾动脉压力在160至40 mmHg之间变化对肾血流量和肾素释放的影响。通过双侧颈总动脉闭塞使压力升高，或逐步降低压力，并使用可充气的肾动脉袖带控制系统将压力维持恒定。当肾动脉压力保持恒定且肾脏中的β受体被阻断时，颈总动脉闭塞本身对肾血流量和肾素释放没有影响。在160 mmHg和静息压力之间，肾血流量没有变化；在静息血压和自动调节下限（平均63.9 mmHg）之间，肾血流量略有增加（平均7%），表明肾血流量自动调节效率很高。肾动脉压力与肾素释放之间的关系可以用两个线性部分来近似：在阈值压力（平均：89.8±3.3 mmHg）以上，对压力变化的敏感性较低（平均斜率：-0.69±0.26 ng AI/min/mm Hg）；在阈值压力和60 mmHg之间，对压力变化的敏感性较高（平均斜率：-64.4±20.8 ng AI/min/mm Hg）。在60至40 mmHg之间，肾素释放没有进一步增加。（摘要截断于250字）
