Engelsen B A, Grønning M
Institute of Neurology, University of Bergen, University Hospital, Norway.
Seizure. 1997 Oct;6(5):377-82. doi: 10.1016/s1059-1311(97)80037-4.
The exact prevalence of epileptic seizures in patients with multiple sclerosis (MS) is still a matter of some controversy. In a population-based, unselected group of 423 patients with MS we identified 17 (4.02%) with epileptic seizures. The mean age at onset of MS was 25.2 years and at onset of epilepsy 32.6 years. A prevalence of 'active epilepsy', i.e. seizures within the last 5 years, was estimated to 3.2%. The prevalence of epilepsy in our MS population is much higher than should be expected when compared to lifetime prevalence of epilepsy in corresponding age groups. The occurrence of convulsive status epilepticus is also higher than expected, and suggests a rather serious prognosis. Thus, drug treatment should be considered after the first epileptic seizure.
多发性硬化症（MS）患者中癫痫发作的确切患病率仍存在一些争议。在一组基于人群、未经筛选的423例MS患者中，我们确定了17例（4.02%）有癫痫发作。MS发病的平均年龄为25.2岁，癫痫发作的平均年龄为32.6岁。“活动性癫痫”（即过去5年内发作）的患病率估计为3.2%。与相应年龄组癫痫的终生患病率相比，我们MS人群中癫痫的患病率要高得多。惊厥性癫痫持续状态的发生率也高于预期，提示预后相当严重。因此，首次癫痫发作后应考虑药物治疗。
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