Kinnunen E, Wikström J
Epilepsia. 1986 Nov-Dec;27(6):729-33. doi: 10.1111/j.1528-1157.1986.tb03602.x.
An analysis of 599 clinically definite multiple sclerosis (MS) patients including all known cases of the southern province of Finland in January 1, 1979 revealed epileptic seizures in 21 (3.5%) patients. On that date, 12 patients needed treatment (2.0%). The age-adjusted prevalence of active epilepsy was significantly higher than that in the general population. The percentage of partial seizures (67%) was significantly increased in proportion to a series of 100 adult epilepsy patients, with a comparable age distribution. In 10 patients (including three patients with symptomatic epilepsy), the attacks appeared before the MS symptoms. The mean follow-up after the first seizures was 19.3 years. In 10 patients, the seizures disappeared totally during the surveillance until September 1985. Our results show an increased comorbidity between MS and epilepsy. In most cases, however, the prognosis of epilepsy was good and there seemed not to be any clear correlation between the severity of MS and epilepsy.
对599例临床确诊的多发性硬化症（MS）患者进行分析，其中包括芬兰南部省份1979年1月1日所有已知病例，结果显示21例（3.5%）患者出现癫痫发作。在该日期，12例患者需要治疗（2.0%）。年龄调整后的活动性癫痫患病率显著高于普通人群。与一系列100例年龄分布相当的成年癫痫患者相比，部分性发作的比例（67%）显著增加。10例患者（包括3例症状性癫痫患者）的发作先于MS症状出现。首次发作后的平均随访时间为19.3年。10例患者在监测至1985年9月期间癫痫发作完全消失。我们的结果表明MS与癫痫的合并症增加。然而，在大多数情况下，癫痫的预后良好，MS的严重程度与癫痫之间似乎没有明显的相关性。
