骨骼发生的遗传学

Genetics of skeletogenesis.

作者信息

Karsenty G

机构信息

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.

出版信息

Dev Genet. 1998;22(4):301-13. doi: 10.1002/(SICI)1520-6408(1998)22:4<301::AID-DVG1>3.0.CO;2-A.

DOI:10.1002/(SICI)1520-6408(1998)22:4<301::AID-DVG1>3.0.CO;2-A

PMID:9664683

Abstract

Major advances have been made in the last 10 years in the genetics of skeletogenesis. This has followed the general progress in our understanding of the genetic control of development in chicken and mouse and more recent advances in human genetics. This large field now encompasses three smaller but distinct fields of investigation. Those are skeleton patterning, cell differentiation in the skeleton, and cell function in the skeleton. This review focuses primarily on advances in understanding cell differentiation and cell function in the skeleton at the genetic level.

摘要

在过去十年中，骨骼发生遗传学取得了重大进展。这是在我们对鸡和小鼠发育的遗传控制的理解取得总体进展以及人类遗传学取得最新进展之后实现的。这个广阔的领域现在涵盖了三个较小但不同的研究领域。它们是骨骼模式形成、骨骼中的细胞分化以及骨骼中的细胞功能。本综述主要关注在遗传水平上对骨骼中细胞分化和细胞功能的理解方面的进展。