Hirata M, Kita Y, Saito S, Nishimura M, Ito M, Mizuta K, Tanaka H, Harihara Y, Kawarasaki H, Hashizume K, Makuuchi M
Second Department of Surgery, Faculty of Medicine, University of Tokyo, Japan.
Transpl Int. 1998;11 Suppl 1:S185-8. doi: 10.1007/s001470050457.
We monitored the serial changes of natural killer cell (NK) activity in eight recipients of living-related liver transplantation. The HLA types of all eight patients were haplotypically identical with those of their donors. Tacrolimus and methylprednisolone were used for immunosuppression. The NK activity before transplantation was 24.1 +/- 20.2% which is surprisingly low when compared with the value for normal individuals (67.7 +/- 13.2%, P < 0.01) or a liver dysfunction group (49.4 +/- 21.9%, P < 0.05). Serial changes in NK activity revealed a minimum of 6.1 +/- 3.6% 1 week after transplantation, gradually increasing to 49.2 +/- 12.5% at 2 months after transplantation. These results suggest that the diseased liver might play an important role in the suppression of NK activity.
我们监测了8例活体亲属肝移植受者自然杀伤细胞（NK）活性的系列变化。所有8例患者的HLA类型与其供者的单倍型完全相同。使用他克莫司和甲基强的松龙进行免疫抑制。移植前NK活性为24.1±20.2%，与正常个体的值（67.7±13.2%，P<0.01）或肝功能障碍组（49.4±21.9%，P<0.05）相比，该值出奇地低。NK活性的系列变化显示，移植后1周最低为6.1±3.6%，移植后2个月逐渐增至49.2±12.5%。这些结果表明，患病肝脏可能在NK活性抑制中起重要作用。
