中脑导水管周围灰质和延髓头端腹内侧部的μ和κ阿片受体

Mu and kappa opioid receptors in periaqueductal gray and rostral ventromedial medulla.

作者信息

Gutstein H B, Mansour A, Watson S J, Akil H, Fields H L

机构信息

Mental Health Research Institute, The University of Michigan, Ann Arbor 48109-0720, USA.

出版信息

Neuroreport. 1998 Jun 1;9(8):1777-81. doi: 10.1097/00001756-199806010-00019.

DOI:10.1097/00001756-199806010-00019

PMID:9665599

Abstract

The periaqueductal gray (PAG) and rostral ventromedial medulla (RVM) are important brain stem pain modulating regions. Recent evidence suggests that kappa opioids antagonize the effects of mu opioids in the RVM. However, the anatomical relationship between mu and kappa opioid receptors in PAG and RVM is not well characterized. This study examined relationships between mu and kappa opioid receptor immunoreactivity (IR) and mRNA in PAG and RVM. Brain slices were processed for either immunocytochemistry or in situ hybridization. We found considerable anatomical overlap of mu and kappa opioid IR and mRNA in the RVM and PAG. These results provide an anatomical basis for recent behavioral and electrophysiological findings in RVM, and suggest modulatory interactions between mu and kappa opioids in PAG.

摘要

中脑导水管周围灰质（PAG）和延髓头端腹内侧区（RVM）是重要的脑干疼痛调节区域。最近的证据表明，κ阿片类物质可拮抗RVM中μ阿片类物质的作用。然而，PAG和RVM中μ和κ阿片受体之间的解剖关系尚未得到充分表征。本研究检测了PAG和RVM中μ和κ阿片受体免疫反应性（IR）与mRNA之间的关系。脑片进行免疫细胞化学或原位杂交处理。我们发现RVM和PAG中μ和κ阿片IR及mRNA存在相当大的解剖学重叠。这些结果为RVM最近的行为和电生理研究结果提供了解剖学基础，并提示PAG中μ和κ阿片类物质之间存在调节性相互作用。