Fijen C A, Kuijper E J, Dankert J, Daha M R, Caugant D A
Department of Medical Microbiology, University of Amsterdam, The Netherlands.
J Clin Microbiol. 1998 Aug;36(8):2342-5. doi: 10.1128/JCM.36.8.2342-2345.1998.
Serotyping and serosubtyping of meningococci showed no difference between isolates from 44 complement-deficient persons and from 50 complement-sufficient persons with meningococcal disease. Multilocus enzyme electrophoretic typing of the meningococci revealed 54 electrophoretic types that were equally distributed among isolates from complement-deficient and complement-sufficient patients. Analysis of strains isolated from eight complement-deficient persons with 11 recurrences of meningococcal disease showed that one strain was identical to the strain previously isolated from the same individual. Our results indicate that there are no differences between the clonal distributions of strains infecting complement-deficient and complement-sufficient patients. Most recurrences were infections caused by different strains.
脑膜炎球菌的血清分型和血清亚型分析显示,44例补体缺陷患者与50例补体充足的脑膜炎球菌病患者分离出的菌株之间没有差异。对脑膜炎球菌进行多位点酶电泳分型,发现54种电泳型在补体缺陷和补体充足患者的分离菌株中分布均匀。对8例有11次脑膜炎球菌病复发的补体缺陷患者分离出的菌株进行分析,结果显示有1株与之前从同一患者分离出的菌株相同。我们的结果表明,感染补体缺陷和补体充足患者的菌株的克隆分布没有差异。大多数复发是由不同菌株引起的感染。