[Ophthalmic-pharmacological complications (author's transl)].

The action of some drugs on the eye may lead to the occurrence of unforeseen ocular and extraocular reactions. Vincaleukoblastin (Velbe) provokes serious corneal lesions with a healing time of two weeks and a half. The local application of Neo-Synephrine eye drops (10%) and Mydrial-Atropine ointment may lead in the case of a pharmacogenetic disposition to disagreeable systemic effects. In one case of preparation for a cataract operation by akinesis and retrobulbar injection, Novocain was changed by mistake with Pilocarpinum hydrochloricum by the error of a pharmaceutical firm. This led to severe complications, which could by successfully treated with Chlorpromazine (Largactil). The knowledge of these clinical observations may be of greater usefulness in the preventation of untoward drug reactions.