Ostrander M M, Hartman J, Badiani A, Robinson T E, Gnegy M E
Neuroscience and Biopsychology Programs, Departments of Psychology and Pharmacology, The University of Michigan, 525 East University St. , Ann Arbor, MI 48109-1109, USA.
Brain Res. 1998 Jun 29;797(2):339-41. doi: 10.1016/s0006-8993(98)00386-2.
Rats were given repeated infusions of i.v. amphetamine in association with placement in a novel test environment, a protocol that produces behavioral sensitization, or in the home cage, a protocol that fails to induce sensitization. In several brain areas amphetamine altered calmodulin content, but only in the group treated in a novel environment, suggesting that amphetamine-induced alterations in calmodulin may occur only when drug treatments induce behavioral sensitization.