环境对反复给予苯丙胺处理的大鼠脑内钙调蛋白变化的影响。

The effect of environment on the changes in calmodulin in rat brain produced by repeated amphetamine treatment.

作者信息

Ostrander M M, Hartman J, Badiani A, Robinson T E, Gnegy M E

机构信息

Neuroscience and Biopsychology Programs, Departments of Psychology and Pharmacology, The University of Michigan, 525 East University St. , Ann Arbor, MI 48109-1109, USA.

出版信息

Brain Res. 1998 Jun 29;797(2):339-41. doi: 10.1016/s0006-8993(98)00386-2.

DOI:10.1016/s0006-8993(98)00386-2

PMID:9666166

Abstract

Rats were given repeated infusions of i.v. amphetamine in association with placement in a novel test environment, a protocol that produces behavioral sensitization, or in the home cage, a protocol that fails to induce sensitization. In several brain areas amphetamine altered calmodulin content, but only in the group treated in a novel environment, suggesting that amphetamine-induced alterations in calmodulin may occur only when drug treatments induce behavioral sensitization.

摘要

给大鼠反复静脉注射苯丙胺，并将其置于新的测试环境中（该方案可产生行为敏化），或置于饲养笼中（该方案无法诱导敏化）。在几个脑区中，苯丙胺改变了钙调蛋白的含量，但仅在新环境中接受处理的组中出现这种情况，这表明苯丙胺诱导的钙调蛋白改变可能仅在药物处理诱导行为敏化时才会发生。