Burge C B, Karlin S
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA.
Curr Opin Struct Biol. 1998 Jun;8(3):346-54. doi: 10.1016/s0959-440x(98)80069-9.
Genome sequencing efforts will soon generate hundreds of millions of bases of human genomic DNA containing thousands of novel genes. In the past year, the accuracy of computational gene-finding methods has improved significantly, to the point where a reasonable approximation of the gene structures within an extended genomic region can often be predicted in advance of more detailed experimental studies.
基因组测序工作很快将产生数亿个碱基的人类基因组DNA，其中包含数千个新基因。在过去的一年里，计算基因发现方法的准确性有了显著提高，以至于在进行更详细的实验研究之前，通常可以预先预测扩展基因组区域内基因结构的合理近似值。
