Motta R, Louis J P, Frank G, Henrotte J G
Laboratoire de Recherches Génétiques sur les Modèles Animaux (LRGMA) Centre de Transgénose, CNRS, Orléans, France.
Growth Dev Aging. 1998 Spring-Summer;62(1-2):37-45.
Two recently described mouse strains, with high (MGH) and low (MGL) blood magnesium (Mg) levels were obtained by selection over 19 generations. Both strains exhibit strong differences for characteristics generally known to be related to blood Mg levels, such as increased stress sensitivity and stress-induced aggressivity in MGL mice. In contrast, while experimental Mg deficiency due to low oral Mg intake has been shown to shorten life span and lower reproductive ability, reproductive longevity was longer in the MGL than in the MGH strain. Interestingly, the life spans of the two strains are very similar. Although this character could have been fixed in the strains by chance, with no relationship to the blood Mg level, the possibility of a causal link with the selection cannot be ruled out and is discussed. Regardless of the mechanisms at stake, the MGH and MGL strains appear to constitute a new model for the study of the relationships between reproductive longevity and blood Mg levels.
通过19代的选育，获得了最近描述的两种小鼠品系，其血液镁（Mg）水平分别较高（MGH）和较低（MGL）。这两种品系在通常已知与血液镁水平相关的特征方面表现出强烈差异，例如MGL小鼠的应激敏感性增加和应激诱导的攻击性增强。相比之下，虽然低口服镁摄入量导致的实验性镁缺乏已被证明会缩短寿命并降低生殖能力，但MGL品系的生殖寿命比MGH品系更长。有趣的是，这两个品系的寿命非常相似。虽然这个特征可能是偶然在品系中固定下来的，与血液镁水平无关，但不能排除与选育存在因果联系的可能性，并对此进行了讨论。无论涉及何种机制，MGH和MGL品系似乎构成了一个研究生殖寿命与血液镁水平之间关系的新模型。
