Frisius H, Al-Abadi H, Heidrich H
Klin Wochenschr. 1976 Sep 15;54(18):895-7. doi: 10.1007/BF01483592.
The disaccharidase activity of the small bowel mucosa of the rat is decreased by intraperitoneal application of Bencyclan-hydrogenfumarate. The doses applied were 10, 50 and 100 mg/kg body weight. The decrease rate after 100 mg/kg attained up to 50% of the control values. Furthermore, a reduction of villous height and an increase of the crypt depth has been observed in correlation with the enzyme activity decrease. Though functional and morphological alterations show a correlation, they cannot be explained by an antimetabolic-like effect because of the fact that the enzyme function recovers 72 h after application of the drug. Whilst our results do not sustain a cytostatic effect of Bencyclan-hydrogenfumarate, there is no doubt that the intraperitoneally applied drug influences the disaccharidase activity. These facts have to be considered in clinical therapy.
腹腔注射富马酸苄环己酯可降低大鼠小肠黏膜的双糖酶活性。给药剂量分别为10、50和100mg/kg体重。100mg/kg剂量给药后，双糖酶活性下降率高达对照值的50%。此外，还观察到绒毛高度降低和隐窝深度增加，且与酶活性下降相关。尽管功能和形态学改变存在相关性，但由于给药72小时后酶功能恢复，因此不能用类似抗代谢的作用来解释。虽然我们的结果不支持富马酸苄环己酯具有细胞抑制作用，但腹腔注射该药物无疑会影响双糖酶活性。在临床治疗中必须考虑这些事实。
