用C组链球菌对豚鼠进行实验性颈淋巴结炎诱导

Experimental induction of cervical lymphadenitis in guinea-pigs with group C streptococci.

作者信息

Olson L D, Schueler R L, Riley G M, Morehouse L G

出版信息

Lab Anim. 1976 Jul;10(3):223-31. doi: 10.1258/002367776781035251.

Abstract

Streptococcal lymphadenitis with macroscopic abscesses was induced in guinea-pigs when an isolate of Lancefield's group C streptococci of guinea-pig origin was sprayed orally. The disease was also produced in guinea-pigs when another isolate was injected sublingually but not when it was sprayed orally. Treatment with prednisolone did not increase the susceptibility to the latter isolant when sprayed orally. Abscesses could not be induced in the cervical lymph nodes of guinea-pigs exposed by injecting group E streptococci sublingually, although the organism was isolated from the cervical lymph nodes 2 days after inoculation. Neither could abscesses be induced by injecting these streptococci sublingually in guinea-pigs treated with prednisolone.

摘要

当将源自豚鼠的兰斯菲尔德C组链球菌分离株经口喷雾时，可在豚鼠中诱发伴有肉眼可见脓肿的链球菌性淋巴结炎。当另一分离株经舌下注射时，也可在豚鼠中引发该病，但经口喷雾时则不会。口服泼尼松龙治疗不会增加经口喷雾时对后一种分离株的易感性。经舌下注射E组链球菌使豚鼠暴露后，虽在接种2天后从其颈淋巴结中分离出了该菌，但未能在豚鼠的颈淋巴结中诱发脓肿。在用泼尼松龙治疗的豚鼠中经舌下注射这些链球菌也不能诱发脓肿。